Web12 sep. 2003 · Bayliss commented recently on hepatocellularity values, emphasizing the uncertainty of interspecies scaling and indicating that appropriate scaling factors remain to be clarified. Therefore, although the value of 120 × 10 6 cells per gram of liver has often been used in human IVIVE [ 18, 19 ], its accuracy in relation to interindividual differences … Web1 aug. 1997 · Microsomal protein recovery and hepatocellularity have been determined and investigated as scaling factors for interrelating clearance by hepatic microsomes, freshly isolated hepatocytes and whole liver from untreated (UT) rats and rats treated with either the cytochrome P450 inducer phenobarbital (PB) or dexamethasone (DEX).
Effect of Age on The Hepatocellularity Number for Wistar rats
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In Vitro - in Vivo Extrapolation of Hepatic Clearance in Preclinical ...
WebHepatocellularity numbers were calculated from the ratio between the liver protein concentration and the protein concentration in the corresponding hepatocyte suspension. … Webhepatocellularity - Wiktionary hepatocellularity English [ edit] Etymology [ edit] hepato- + cellularity Noun [ edit] hepatocellularity ( uncountable ) The condition of being hepatocellular This page was last edited on 11 March 2024, at 09:48. Text is available under the Creative Commons Attribution-ShareAlike License; additional terms may apply. Web1 jan. 2007 · Abstract. Reported predictions of human in vivo hepatic clearance from in vitro data have used a variety of values for the scaling factors human microsomal protein (MPPGL) and hepatocellularity (HPGL) per gram of liver, generally with no consideration of the extent of their inter-individual variability. We have collated and analysed data from a ... router via