Hepatocyte antigen presentation
WebPresentation and recognition of MHC antigen on the surface of cells is the basic process of initiating rejection and distinguishing "self and not self". This is considered to … Web2 jul. 2007 · Hepatocytes express CD1d and present lipid antigens to NKT cells. Depletion and dysregulation of hepatic NKT cells occurs in mice with fatty livers. Herein, we assess whether reduced CD1d content...
Hepatocyte antigen presentation
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WebPresentation of Antigens on Major Histocompatibility Complex (MHC) Molecules Liver Sinusoidal Endothelial Cells Due to the direct contact with blood and its carried … Web25 okt. 2010 · Hepatocyte DNA released from damaged cells has been identified as an endogenous ligand of TLR9 that promotes mDCs to secrete IL-10 (Ref. 60 ), which decreases the production of IL-6, TNF and...
Web15 jul. 2005 · Hepatocytes express abundant surface class I MHC and efficiently use transporter associated with antigen processing, tapasin, and low molecular weight … Web11 mei 2009 · Antigen presenting cells express a finite number of MHC molecules on their surfaces, thus foreign proteins must compete with endogenously derived products for antigen presentation. It was therefore important to determine the binding affinity and detection limit of TCR multimers for pMHC complexes.
Web4 apr. 2016 · Hepatocytes exert antigen-presenting properties, which are unique for parenchymal cells. 112, 113 Hepatocytes express low levels of MHC-I molecules under homeostatic conditions, which may... WebAlthough antigen presentation was modest, it was sufficient to flag transduced cells for CTL-mediated lysis in an in vitro killing assay. Destruction of hepatocytes was inhibited …
Web13 apr. 2024 · Colorectal cancer stem cells can perform immune escape by inhibiting the antigen presentation ability of DCs. Zhong et al. show that TGF-β1 derived from spheres of high-stemness colorectal cancer cell lines CMT93 and CT26 down-regulates the surface expression of major histocompatibility complex Class II of bone marrow derived DCs …
Web12 okt. 2024 · Surprisingly, antigen presentation by hepatocytes is more important than cross-presentation by hematopoietic cells for the induction of HBV-specific CD8 + … laws that help businessesWeb1 apr. 2007 · We observed that hepatocyte antigen presentation was generally inefficient, and the quantity of viral antigen strongly influenced CD8 T-cell antiviral function. laws that impact public administrationWebHepatocyte specific antigens are useful in studying hepatocellular tumors. They may be useful in differentiating clear cell hepatocellular carcinomas from other clear cell malignancies. They have been shown in the … kaseya in the newslaws that impact immigrantsWeb9 sep. 2024 · Fasano, M et al. "Immunohistochemical evaluation of hepatoblastomas with use of the hepatocyte-specific marker, hepatocyte paraffin 1, and the polyclonal anti-carcinoembryonic antigen." Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc vol. 11,10 (1998): 934-8. laws that led to mass incarcerationWeb3 mrt. 2024 · Hepatocytes compose up to 80% of the total liver and have been indicated as important players in the induction of immunologic tolerance in this organ. We show that … laws that must be changedWebBecause hepatocytes are susceptible to noncytolytic mechanisms of viral clearance, CD8 T-cell antiviral efficiency against hepatotropic viruses has been linked to their capacity to … laws that martin luther king jr helped change