Idiosyncratic toxicity meaning
Web20 mrt. 2024 · Idiosyncratic toxicity can occur when a convergence of risk factors, including drug exposure, tips the risk-benefit balance away from benefit and toward risk. … WebIt has been proposed that some idiosyncratic reactions, especially those involving the liver, represent metabolic idiosyncrasy; however, there are even less data to support this hypothesis. The unpredictable nature of these reactions makes mechanistic studies difficult.
Idiosyncratic toxicity meaning
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WebAbstractThe therapeutic margin for any drug is based on both toxicity and efficacy. Generally, toxicity is dose-dependent and is driven either by the therapeutic target or by … WebGiven that the definition of an idiosyncratic ADR means that these reactions are ... Shear NH, Spielberg SP, Grant DM, Tang BK, Kalow W. Differences in metabolism of …
Web“Idiosyncrasy” is a word from Greek voices idios, “Singular”, and synkrasis, “Temperament”, and It was used for the first time in Spanish in 1861, by the writer of Hispanic origin … WebDisorder. Now somewhere between the sacred silence. Sacred silence and sleep. Somewhere, between the sacred silence and sleep. Disorder, disorder, disorder. More …
Web11 jan. 2007 · Generally, toxicity is dose-dependent and is driven either by the therapeutic target or by an untoward target. However, idiosyncratic toxicities are usually not observed until a drug has been on the market and has gained broad exposure. WebPrevention. Adverse drug reaction (ADR, or adverse drug effect) is a broad term referring to unwanted, uncomfortable, or dangerous effects that drugs (including medications ) may have. Adverse drug reactions can be considered a form of toxicity; however, toxicity is most commonly applied to effects of overingestion (accidental or intentional ...
Webintoxication [in-tok″sĭ-ka´shun] 1. stimulation, excitement, or impaired judgment caused by a chemical substance, or as if by one. 2. substance intoxication, especially that due to …
WebIdiosyncratic toxicity can occur when a convergence of risk factors, including drug exposure, tips the risk-benefit balance away from benefit and toward risk. Keywords adverse drug reaction, drug-induced liver injury, idiosyncratic drug reaction deputy district attorney jon hatamiWeb1 dec. 2009 · However, idiosyncratic toxicity is not reproducible in conventional nonclinical animal studies and can be observed in a small number of patients during clinical studies. It is also known that... deputy district attorney leslie gutierrezWeb6 feb. 2024 · An abnormally exaggerated response, or an abnormal lack of response. A response unusual because it requires an unusually small or unusually large dose. An … deputy district attorney jobWeb10 jun. 2024 · There was no obvious link between idiosyncratic toxicity and physicochemical properties such as molecular weight, lipophilicity, etc. Approximately … deputy district attorney kayla wildemanWeb7 jul. 2024 · zany • ZAY-nee • noun. 1 : a subordinate clown or acrobat in old comedies who mimics ludicrously the tricks of the principal 2 : one who acts the buffoon to … deputy district attorney lane county oregonWeb10 mei 2013 · Idiosyncratic drug toxicity (IDT), which is one of them, is too difficult to be predicted before a clinical study is conducted. ... This means that the covalent binding experiment using even S9 other than HLM does not suitably reflect live liver cells. fibe-miniWebIdiosyncratic drug reactions account for the majority of hepatotoxicity associated with drugs worldwide. Idiosyncratic drug reaction occurs in very few individuals exposed to drugs … fi benchmark