Targeting telomerase for cancer therapy
WebApr 5, 2013 · Summary and conclusions—prospects for cancer therapy. The expression of telomerase in various human cancers and its diminished expression in most normal cells … WebMar 3, 2024 · Human telomerase reverse transcriptase (hTERT) is overexpressed in the majority of tumors and a potential target for adoptive cell therapy. We isolated a novel hTERT-specific TCR sequence, named Radium-4, from a clinically responding pancreatic cancer patient vaccinated with a long hTERT peptide. Radium-4 TCR-redirected primary …
Targeting telomerase for cancer therapy
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WebAug 1, 2011 · Request PDF Targeting Telomerase for Cancer Therapy The ribonucleoprotein, telomerase, prevents genomic instability by adding telomere repeats at the end of chromosomes. Although the ... WebMar 29, 2024 · Telomerase inhibition is a good and specific target. Because the telomerase is not detected in most normal tissues [2, 17], differences in telomerase expression, telomere length, and cell kinetics between normal and cancer tissues suggest that targeting telomerase for cancer therapy may be relatively safe .
WebSep 4, 2007 · Telomerase activity is elevated in the vast majority of tumors, and telomeres are critically shortened in tumors versus normal tissues, thus providing a compelling rationale to target the telomerase/telomere pathway for broad-spectrum cancer therapy. This strategy is supported by a variety of genetic-based target validation studies. WebMar 30, 2010 · A hallmark of cancer cells is their ability to prevent telomere shortening. Sometimes this is achieved without telomerase by a process known as alternative lengthening of telomeres (ALT). Recent ...
WebTelomerase is a suitable target for drug development because of its high prevalence, selective expression, and mechanistic importance in many cancer types. Telomerase targeting strategies can be defi ned as immunotherapy, gene therapy, and inhibition either by oligonucleotides or small molecules. However, few published approaches have entered … WebNov 17, 2024 · Since telomerase is active in cancer cells but not normal cells, it is seen as a promising target for cancer therapy. Due to telomerase inhibition, activity, or expression, targeted drugs might kill tumor cells by allowing telomeres to shrink or by provoking apoptosis. To that end, scientists have been investigating what genes and other factors ...
WebApr 14, 2024 · Overall, telomerase is still a desirable target for cancer therapy despite major obstacles. Studies should concentrate on creating better inhibitors in conjunction with …
WebAug 1, 2011 · Request PDF Targeting Telomerase for Cancer Therapy The ribonucleoprotein, telomerase, prevents genomic instability by adding telomere repeats at … pocket acetone for pursesWebJul 30, 2024 · Telomerase has been considered an attractive target for cancer therapy since the discovery over 20 years ago that reactivation of this enzyme in cancer cells mediates … pocket al chatWebApr 22, 2024 · Targeting telomerase for cancer therapy. Ideal cancer therapeutic targets are those that are specific for certain tumors and that pose a threat for maintaining its malignancy. As a role of ... pocket actionWebDec 11, 2024 · Telomerase-targeted Cancer Immunotherapy. Because upregulated telomerase activity is significant in tumor cells, hTERT makes an attractive tumor antigen for telomerase targeted cancer … pocket activity trackerWebNov 1, 2024 · As telomerase is constitutively expressed in many human cancers, telomerase-targeting therapy has been considered to be a potentially promising approach for cancer treatment . However, a limited number of chemical compounds that target telomerase or telomeres have been identified and only some of these are in clinical trials. pocket afro pickWebFeb 25, 2024 · This review aims to introduce a new target of hDPSC-based therapy on the recipient niche function in SLE. Recent advances in mesenchymal stem/stromal cell (MSC) research have led us to consider the feasibility of MSC-based therapy for various diseases. ... targeting telomerase activity in recipient BMMSCs may be a novel therapeutic option … pocket agencyWebNational Center for Biotechnology Information pocket action camera